Molecular aspects of monoamine oxidase B

Molecular aspects of monoamine oxidase B Rona

An evaluation of phospholipids as regulators of monoamine oxidase A and monoamine oxidase B activities.

When rat liver mitochondria are treated with the phospholipase A2 isolated from Naja naja venom in amounts sufficient to cause about 70% loss of mitochondrial phospholipids, both of the monoamine oxidase isozymes monoamine oxidase A and monoamine oxidase B are reduced in activity. With both monoamine oxidases, phospholipase treatment affects the enzyme’s affinity for the amine substrates rather...

Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats.

Although nicotine is considered to be responsible for the addictive properties of tobacco, growing evidence underlines the importance of non-nicotine components in smoking reinforcement. It has been shown that tobacco smoke contains monoamine oxidase (MAO) A and B inhibitors and decreases MAO-A and MAO-B activity in smokers. Here, we investigated the effects of clorgyline hydrochloride (irrever...

Inhibition of monoamine oxidase by stilbenes from Rheum palmatum

Seven stilbenes and one catechin were bioactivity-guidedly isolated from the rhizomes of Rheum palmatem. Their structures were identified as piceatannol(1), resveratrol(2), piceid(3), rhapontigenin(4), piceatannol-3'-O-β-D-glucopyranoside(5), rhaponticin(6), catechin(7) and desoxyrhapontigenin(8). Anti-monoamine oxidase (MAO) activities of compounds 1–8 were tested. Compounds 1 and 8 showed sig...

Inhibition of monoamine oxidase by stilbenes from Rheum palmatum

Seven stilbenes and one catechin were bioactivity-guidedly isolated from the rhizomes of Rheum palmatem. Their structures were identified as piceatannol(1), resveratrol(2), piceid(3), rhapontigenin(4), piceatannol-3'-O-β-D-glucopyranoside(5), rhaponticin(6), catechin(7) and desoxyrhapontigenin(8). Anti-monoamine oxidase (MAO) activities of compounds 1–8 were tested. Compounds 1 and 8 showed sig...